Imports System.Data.OleDb
Public Class Form1
    Private Sub Button1_Click(ByVal sender As System.Object, ByVal e As System.EventArgs) Handles Button1.Click
        Dim connetionString As String
        Dim cnn As OleDbConnection
        Dim cmd As OleDbCommand
        Dim sql As String

        connetionString = "Provider=Microsoft.Jet.OLEDB.4.0;Data Source=Your mdb filename;"
        sql = "Your SQL Statement Here"

        cnn = New OleDbConnection(connetionString)
        Try
            cnn.Open()
            cmd = New OleDbCommand(sql, cnn)
            cmd.ExecuteNonQuery()
            cmd.Dispose()
            cnn.Close()
            MsgBox(" ExecuteNonQuery in OleDbConnection executed !!")
        Catch ex As Exception
            MsgBox("Can not open connection ! ")
        End Try
    End Sub
End Class