Imports System.Data.Odbc

Public Class Form1

    Private Sub Button1_Click(ByVal sender As System.Object, ByVal e As System.EventArgs) Handles Button1.Click

        Dim connetionString As String

        Dim cnn As OdbcConnection

        connetionString = "Driver={Microsoft Access Driver (*.mdb)};DBQ=yourdatabasename.mdb;"

        cnn = New OdbcConnection(connetionString)

        Try

            cnn.Open()

            MsgBox("Connection Open ! ")

            cnn.Close()

        Catch ex As Exception

            MsgBox("Can not open connection ! ")

        End Try

    End Sub

End Class