Public Class Form1 Private Sub Button1_Click(ByVal sender As System.Object, ByVal e As System.EventArgs) Handles Button1.Click Dim CDOSYS As Object Const cdoSendUsingPickup = 1 Const strPickup = "c:\inetpub\mailroot\pickup" CDOSYS = CreateObject("CDO.Message") CDOSYS.Configuration.Fields.item _ ("http://schemas.microsoft.com/cdo/configuration/sendusing") _ = cdoSendUsingPickup CDOSYS.Configuration.Fields.item _ ("http://schemas.microsoft.com/cdo/configuration" & _ /smtpserverpickupdirectory") _ = strPickup CDOSYS.Configuration.Fields.Update() CDOSYS.To = "TO ADDRESS" CDOSYS.From = "FROM ADDRESS" CDOSYS.Subject = "CDO Test" CDOSYS.TextBody = "Send Email from vb.net using CDOSYS" CDOSYS.Send() CDOSYS = Nothing MsgBox("mail send") End Sub End Class