Imports System.Data
Public Class Form1
    Private Sub Button1_Click(ByVal sender As System.Object, _
                ByVal e As System.EventArgs) Handles Button1.Click
        Try
            Dim MyConnection As System.Data.OleDb.OleDbConnection
            Dim myCommand As New System.Data.OleDb.OleDbCommand
            Dim sql As String

            MyConnection = New System.Data.OleDb.OleDbConnection _
            ("provider=Microsoft.Jet.OLEDB.4.0; Data Source=" + _
            "'c:\testfile.xls';Extended Properties=Excel 8.0;")

            MyConnection.Open()
            myCommand.Connection = MyConnection
            sql = "Update [Sheet1$] set name = 'New Name' where id=1"
            myCommand.CommandText = sql
            myCommand.ExecuteNonQuery()
            MyConnection.Close()
        Catch ex As Exception
            MsgBox(ex.ToString)
        End Try
        MsgBox("Updated ")
    End Sub
End Class